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KMID : 0848120100350040191
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International Journal of Oral Biology
2010 Volume.35 No. 4 p.191 ~ p.195
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Antimicrobial Effects of Oleanolic Acid against Streptococcus mutans and Streptococcus sobrinus Isolated from a Korean Population
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Kim Min-Jung
Kim Chun-Sung
Ha Woo-Hyung
Kim Byung-Hoon
Lim Yun-Kyong
Park Soon-Nang
Cho Yu-Jin
Kim Myung-Mi
Ko Jang-Hyuk
Kwon Soon-Sung
Ko Yeong-Mu
Kook Joong-Ki
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Abstract
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Oleanolic acid is a natural triterpenoid that exists widely in foods and some medicinal herbs. The purpose of this study was to determine the antimicrobial activity of oleanolic acid against Streptococcus mutans strains isolated from a Korean population. Antimicrobial activity against these bacteria was evaluated by minimal inhibitory concentration (MIC) and time kill curves. The tolerance of human gingival fibroblasts and human periodontal ligaments to oleanolic acid was tested using a methyl thiazolyl tetrazolium (MTT) assay. The value of oleanolic acid for both S. mutans and S. sobrinus isolated from Koreans was 8 . Oleanolic acid showed bactericidal effects against S. mutans ATCC and S. sobrinus ATCC at () and had no cytotoxic effects against KB cells at this dose. The results suggest that oleanolic acid could be useful in the future development of oral hygiene products for the prevention of dental caries.
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KEYWORD
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Antimicrobial effect, oleanolic acid, Streptococcus mutans
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